[Steve]

Anywhere along East Ashley Ave would be ok.
If you work the south end at the county park, I would recommend where the intracoastal opens up, to the NE side of the barriers, watch the current and water color. The more blue, the better. This area might be busier due to it's proximity to the ICW, water generally not as clean. You may have to hike a bit from the parking lot too.

If you are going to the north end (preferred) then work the area around Lighthouse Inlet, some deeper waters there.
This is especially a good area because of the swifter currents that wash bait out and about. But ya gotta' watch that the currents don't sweep you away, stay just to the leeward side and toss into the faster, blue water. The water can really whip around that point. You might even want to scout out the water in between the bars/islands depending on depth. You should be able to find parking near the top end before the road cuts back in.

As for bait, liveline whatever you can legally catch. Cut the bait just behind the anal opening to get it to bleed, put it on a big hook, enough weight to hold bottom and enjoy.

Before you commit, scout it all out, south end first, then north. Find the best described water then go for it.